Associate Professor of Pediatrics Director, Congenital Hyperinsulinism Center

Pediatric Endocrinology

Diva D. Deleon works in the field of Pediatric Endocrinology. Diva Deleon has written publications. She has 32 publications published with PubMed. The lastest paper is: 'Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith-Wiedemann syndrome.'

Publications

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• Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith-Wiedemann Syndrome.
• High Risk of Diabetes and Neurobehavioral Deficits in Individuals With Surgically Treated Hyperinsulinism.
• Recommendations from the Pediatric Endocrine Society for Evaluation and Management of Persistent Hypoglycemia in Neonates, Infants, and Children.
• Re-evaluating "transitional neonatal Hypoglycemia": mechanism and implications for management.
• A novel mutation in GATA6 causes pancreatic agenesis.
• Mechanotransduction drives post ischemic revascularization through K(ATP) channel closure and production of reactive oxygen species.
• A liquid chromatography-mass spectrometry assay for quantification of Exendin[9-39] in human plasma.
• Determination of insulin for the diagnosis of hyperinsulinemic Hypoglycemia.
• Clinical presentation and management of children with diffuse and focal hyperinsulinism: a review of 223 cases.
• A novel atypical presentation of insulin autoimmune Syndrome (Hirata's disease) in a child.
• Monogenic hyperinsulinemic Hypoglycemia: current insights into the pathogenesis and management.
• Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A.
• GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ ch...
• Compound heterozygous mutations in the SUR1 (ABCC 8) subunit of pancreatic K(ATP) channels cause neonatal diabetes by perturbing the coupling between Kir6.2 and SUR1 s...
• Postoperative surveillance and detection of postprandial Hypoglycemia after fundoplasty in children.
• Neonatal Diabetes and Congenital Malabsorptive Diarrhea Attributable to a Novel Mutation in the Human Neurogenin-3 Gene Coding Sequence.
• Calcineurin signaling regulates human islet {beta}-cell survival.
• Use of metformin to control clozapine-associated weight gain in an adolescent with schizoaffective disorder.
• Permanent Neonatal Diabetes Mellitus
• Increased glucagon-like peptide-1 secretion and postprandial Hypoglycemia in children after Nissen fundoplication.
• Exendin-(9-39) corrects fasting Hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.
• A mutation in the TMD0-L0 region of sulfonylurea receptor-1 (L225P) causes permanent neonatal diabetes mellitus (PNDM).
• Preexisting pancreatic acinar cells contribute to acinar cell, but not islet beta cell, regeneration.
• Mechanisms of Disease: advances in diagnosis and treatment of hyperinsulinism in neonates.
• Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus.
• Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3.
• Identification of transcriptional targets during pancreatic growth after partial pancreatectomy and exendin-4 treatment.
• Neonatal exendin-4 prevents the development of diabetes in the intrauterine growth retarded rat.
• Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy.
• Long-term (15 years) outcome in an infant with metastatic adrenocortical carcinoma.
• Free and total insulin-like growth factor (IGF)-I levels decline during fasting: relationships with insulin and IGF-binding protein-1.

Schools

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• Universidad De Panama Facultad De Medicina

• Monmouth Med Center

• Chldns Hospital Phila

Conditions Treated

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• Abnormal Thyroid
• Adrenal Insufficiency
• Adrenogenital Disorders
• Hyperlipidemia
• View All

Doctors Specialties

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• Pediatric Endocrinology

Accepted Insurances

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Education

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• Children's Hospital of Philadelphia
• Monmouth Medical Center
• Universidad de Panama Faculty of Medicine

Hospital

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• Abington Hospital - Jefferson Health
• Hospital of the University of Pennsylvania
• Pennsylvania Hospital

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