Professor Emeritus of Pediatrics, University Pennsylvania
Pediatric Endocrinology
Dr. Charles A. Stanley, MD
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Dr. Charles A. Stanley is an expert in the field of Pediatric Endocrinology. He studied medicine at University of Virginia School of Medicine. He has 1 awards "Super Doctor". Dr. Charles A. Stanley is a published physician. He has 77 publications published. The most current publication "Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith-Wiedemann syndrome."
Publications
- Congenital hyperinsulinism in children with paternal 11p uniparental isodisomy and Beckwith-Wiedemann Syndrome.
- High Risk of Diabetes and Neurobehavioral Deficits in Individuals With Surgically Treated Hyperinsulinism.
- Mitochondrial GTP insensitivity contributes to hypoglycemia in Hyperinsulinemia Hyperammonemia (HI/HA) by inhibiting glucagon release.
- 50 years ago in the journal of pediatrics: ketotic hypoglycemia.
- Multiple phenoTypes in phosphoglucomutase 1 deficiency.
- Determination of insulin for the diagnosis of hyperinsulinemic hypoglycemia.
- Glutamate Dehydrogenase: Structure, Allosteric Regulation, and Role in Insulin Homeostasis.
- Accuracy of PET/CT Scan in the diagnosis of the focal form of congenital hyperinsulinism.
- GenoType and phenoType correlations in 417 children with congenital hyperinsulinism.
- Hypertrophic cardiomyopathy in neonates with congenital hyperinsulinism.
- Measurement of tissue acyl-CoAs using flow-injection tandem mass spectrometry: acyl-CoA profiles in short-chain fatty acid oxidation defects.
- GLP-1 receptor antagonist exendin-(9-39) elevates fasting blood glucose levels in congenital hyperinsulinism owing to inactivating mutations in the ATP-sensitive K+ ch...
- Novel presentations of congenital hyperinsulinism due to mutations in the MODY genes: HNF1A and HNF4A.
- The Value of Radiologic Interventions and (18)F-DOPA PET in Diagnosing and Localizing Focal Congenital Hyperinsulinism: Systematic Review and Meta-Analysis.
- Short-chain 3-hydroxyacyl-coenzyme a dehydrogenase associates with a protein super-complex integrating multiple metabolic pathways.
- Pancreatic head resection and Roux-en-Y pancreaticojejunostomy for the treatment of the focal form of congenital hyperinsulinism.
- The structure and allosteric regulation of mammalian glutamate dehydrogenase.
- Green Tea Polyphenols Control Dysregulated Glutamate Dehydrogenase in Transgenic Mice by Hijacking the ADP Activation Site.
- Glucokinase Activation Repairs Defective Bioenergetics of Islets of Langerhans isolated from Type-2-Diabetics.
- Mutational analysis of allosteric activation and inhibition of glucokinase.
- Diazoxide-Unresponsive Congenital Hyperinsulinism in Children With Dominant Mutations of the {beta}-Cell Sulfonylurea Receptor SUR1.
- Hepatocyte nuclear factor 4α gene mutation associated with familial neonatal hyperinsulinism and maturity-onset Diabetes of the young.
- Nesidioblastosis no longer! It's all about genetics.
- Rare forms of congenital hyperinsulinism.
- A specialized team approach to diagnosis and medical versus surgical treatment of infants with congenital hyperinsulinism.
- Two genetic forms of hyperinsulinemic hypoglycemia caused by dysregulation of glutamate dehydrogenase.
- The structure and allosteric regulation of glutamate dehydrogenase.
- Mechanism of hyperinsulinism in short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency involves activation of glutamate dehydrogenase.
- The hyperinsulinism/hyperammonemia Syndrome.
- Intussusception after pancreatic surgery in children: a case series.
- Research initiatives in neonatal hypoglycemia.
- Pregnancy in glycogen storage disease Type Ib: gestational care and report of first successful deliveries.
- Characterization and functional restoration of a potassium channel Kir6.2 pore mutation identified in congenital hyperinsulinism.
- Regulation of glutamate metabolism and insulin secretion by glutamate dehydrogenase in hypoglycemic children.
- Extremes of clinical and enzymatic phenoTypes in children with hyperinsulinism caused by glucokinase activating mutations.
- Sulfonylurea receptor 1 mutations that cause opposite insulin secretion defects with chemical chaperone exposure.
- Follow-up analysis of genome-wide association data identifies novel loci for type 1 Diabetes.
- Exendin-(9-39) corrects fasting hypoglycemia in SUR-1-/- mice by lowering cAMP in pancreatic beta-cells and inhibiting insulin secretion.
- Poor specificity of low growth hormone and cortisol levels during fasting hypoglycemia for the diagnoses of growth hormone deficiency and adrenal insufficiency.
- Clinical characteristics and biochemical mechanisms of congenital hyperinsulinism associated with dominant KATP channel mutations.
- Elimination of KATP channels in mouse islets results in elevated [U-13C]glucose metabolism, glutaminolysis, and pyruvate cycling but a decreased gamma-aminobutyric aci...
- Destabilization of ATP-sensitive potassium channel activity by novel KCNJ11 mutations identified in congenital hyperinsulinism.
- A novel susceptibility locus for type 1 Diabetes on Chr12q13 identified by a genome-wide association study.
- Hyperinsulinism in infancy and childhood: when an insulin level is not always enough.
- Accuracy of [18F]fluorodopa positron emission tomography for diagnosing and localizing focal congenital hyperinsulinism.
- Congenital hyperinsulinism associated ABCC8 mutations that cause defective trafficking of ATP-sensitive K+ channels: identification and rescue.
- A mutation in the TMD0-L0 region of sulfonylurea receptor-1 (L225P) causes permanent neonatal Diabetes mellitus (PNDM).
- Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.
- Multiple ectopic lesions of focal islet adenomatosis identified by positron emission tomography scan in an infant with congenital hyperinsulinism.
- The diagnosis of ectopic focal hyperinsulinism of infancy with [18F]-dopa positron emission tomography.
- Protein-sensitive hypoglycemia without leucine sensitivity in hyperinsulinism caused by K(ATP) channel mutations.
- Effects of a GTP-insensitive mutation of glutamate dehydrogenase on insulin secretion in transgenic mice.
- Green tea polyphenols modulate insulin secretion by inhibiting glutamate dehydrogenase.
- A novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channels.
- Clinical features and insulin regulation in infants with a Syndrome of prolonged neonatal hyperinsulinism.
- Molecular and immunohistochemical analyses of the focal form of congenital hyperinsulinism.
- Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset Diabetes of the young.
- Effects of hypoglycemia on developmental outcome in children with congenital hyperinsulinism.
- Central nervous system hyperexcitability associated with glutamate dehydrogenase gain of function mutations.
- GenoType-phenoType correlations in children with congenital hyperinsulinism due to recessive mutations of the adenosine triphosphate-sensitive potassium channel genes.
- Evolution of glutamate dehydrogenase regulation of insulin homeostasis is an example of molecular exaptation.
- Carnitine deficiency Disorders in children.
- Congenital hyperinsulinism: intraoperative biopsy interpretation can direct the extent of pancreatectomy.
- Blood glucose control during selective arterial stimulation and venous sampling for localization of focal hyperinsulinism lesions in anesthetized children.
- Familial leucine-sensitive hypoglycemia of infancy due to a dominant mutation of the beta-cell sulfonylurea receptor.
- A signaling role of glutamine in insulin secretion.
- Hyperinsulinism/hyperammonemia Syndrome: insights into the regulatory role of glutamate dehydrogenase in ammonia metabolism.
- A multidisciplinary approach to the focal form of congenital hyperinsulinism leads to successful treatment by partial pancreatectomy.
- Preoperative evaluation of infants with focal or diffuse congenital hyperinsulinism by intravenous acute insulin response tests and selective pancreatic arterial calci...
- Newborn screening by tandem mass spectrometry for medium-chain Acyl-CoA dehydrogenase deficiency: a cost-effectiveness analysis.
- Clinical and molecular characterization of a dominant form of congenital hyperinsulinism caused by a mutation in the high-affinity sulfonylurea receptor.
- Histopathology of congenital hyperinsulinism: retrospective study with genoType correlations.
- Structural studies on ADP activation of mammalian glutamate dehydrogenase and the evolution of regulation.
- Regulation of leucine-stimulated insulin secretion and glutamine metabolism in isolated rat islets.
- Glutaminolysis and insulin secretion: from bedside to bench and back.
- Advances in diagnosis and treatment of hyperinsulinism in infants and children.
Schools
Virginia Commonwealth University School Of Medicine
Children39s Hospital Of Philadelphia
Conditions Treated
- Abnormal Thyroid
- Adrenogenital Disorders
- Diabetes Type 2
- Hyperlipidemia
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Doctors Specialties
- Pediatric Endocrinology
Accepted Insurances
Awards
- Super Doctor
Education
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Children's Hospital of Philadelphia -
University of Virginia School of Medicine
Hospital
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Hospital of the University of Pennsylvania -
Pennsylvania Hospital
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