Herbut Professor and Chair, Department of Pathology, Anatomy and Cell Biology
Pathology
Dr. Stephen C. Peiper, MD
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Stephen Peiper is an expert in the field of Pathology. He graduated from Saint Louis University School of Medicine. Saint Louis University School of Medicine has a rank of 67 in research and a 57 in primary care He received 1 awards: "CMS Meaningful Use Stage 1 Certification". Doctor Stephen C. Peiper, MD is also published. He has 101 publications published. The lastest publication: "CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins.' He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Validation of a Next-Generation-Sequencing Cancer Panel for Use in the Clinical Laboratory.
- Decorin protein core affects the global gene expression profile of the tumor microenvironment in a triple-negative orthotopic breast carcinoma xenograft model.
- Proline-Rich Tyrosine Kinase 2 (Pyk2) Regulates IGF-I-Induced Cell Motility and Invasion of Urothelial Carcinoma Cells.
- The metastasis suppressor KISS1 lacks antimetastatic activity in the C8161.9 xenograft model of melanoma.
- Epidermal growth factor receptor and insulinlike growth factor 1 receptor expression predict poor survival in pancreatic ductal adenocarcinoma.
- Decorin antagonizes IGF-IR function by interfering with IGF-IR activity and attenuating downstream signaling.
- Chromosomal abnormalities in renal cell carcinoma variants detected by Urovysion fluorescence in situ hybridization on paraffin-embedded tissue.
- Role and mechanism of arsenic in regulating angiogenesis.
- Pan-histone deacetylase inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic antimyeloid activity in combination with CXCR4 antagonists.
- Fluorescent imaging of high-grade bladder cancer using a specific antagonist for chemokine receptor CXCR4.
- Activation of Rho and Rho-associated kinase by GPR54 and KiSS1 metastasis suppressor gene product induces changes of cell morphology and contributes to apoptosis.
- KiSS1 metastasis suppressor gene product induces suppression of tyrosine kinase receptor signaling to Akt, tumor necrosis factor family ligand expression, and apoptosis.
- Expression of CXCR4, a G-protein-coupled receptor for CXCL12 in yeast identification of new-generation inverse agonists.
- Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy.
- The use of Urovysion fluorescence in situ hybridization in the diagnosis and surveillance of non-urothelial carcinoma of the bladder.
- Physical association of GPR54 C-terminal with protein phosphatase 2A.
- Development of novel G-protein-coupled receptor 54 agonists with resistance to degradation by matrix metalloproteinase.
- Expression profile of heptahelical putative membrane progesterone receptors in epithelial ovarian tumors.
- Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis.
- Heat shock response in CHO mammalian cells is controlled by a nonlinear stochastic process.
- SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54.
- Requirement of KISS1 secretion for multiple organ metastasis suppression and maintenance of tumor dormancy.
- Structure-activity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists: disclosing the importance of side-chain and backbone functionalities.
- Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and the...
- Characterization of constitutively active mutants of G protein-coupled receptors.
- Functional expression of CXCR4 in Saccharomyces cerevisiae in the development of powerful tools for the pharmacological characterization of CXCR4.
- Kisspeptin-10-induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of ...
- Identification of novel low molecular weight CXCR4 antagonists by structural tuning of cyclic tetrapeptide scaffolds.
- Stereoselective synthesis of [L-Arg-L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isosteres and its application to the synthesis and biological evaluation of ps...
- Metastin and its variant forms suppress migration of pancreatic cancer cells.
- Lipid bilayer simulations of CXCR4 with inverse agonists and weak partial agonists.
- Constitutive activation of CCR5 and CCR2 induced by conformational changes in the conserved TXP motif in transmembrane helix 2.
- Duffy antigen facilitates movement of chemokine across the endothelium in vitro and promotes neutrophil transmigration in vitro and in vivo.
- Fiber optic immunosensors for cardiovascular disease diagnosis: quantification of Protein C, Factor V Leiden, and cardiac Troponin T in plasma.
- CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion.
- A point mutation that confers constitutive activity to CXCR4 reveals that T140 is an inverse agonist and that AMD3100 and ALX40-4C are weak partial agonists.
- Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.
- Role of CD4 hinge region in GP120 utilization by immunoglobulin domain 1.
- Detection of Epstein-Barr virus genomes in lymphomatoid granulomatosis: analysis of 29 cases by the polymerase chain reaction technique.
- Coding sequences of the tal-1 gene are disrupted by chromosome translocation in human T cell leukemia.
- Specific inhibition of interleukin 3 bioactivity by a monoclonal antibody reactive with hematopoietic progenitor cells.
- Molecular cloning, expression, and chromosomal localization of the gene encoding a human myeloid membrane antigen (gp150).
- Malignant rhabdoid tumor of the liver. Evidence for epithelial differentiation.
- Childhood acute lymphoblastic leukemia with chromosomal breakpoints at 11q23.
- Pulmonary involvement in infectious mononucleosis: histopathologic features and detection of Epstein-Barr virus-related DNA sequences.
- Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.
- Hodgkin''s disease monograph.
- Cloning and sequencing of immunoglobulin variable-region genes using degenerate oligodeoxyribonucleotides and polymerase chain reaction.
- Amplification of the gli gene in childhood sarcomas.
- Malignant lymphoma. Summation.
- Auer rods in mature granulocytes: a unique morphologic feature of acute myelogenous leukemia with maturation.
- Markers of cellular differentiation in acute lymphoblastic leukemia.
- Immunoassay of circulating terminal transferase in patients with acute lymphoblastic leukemia: a new technique for diagnosis.
- Determination of terminal deoxynucleotidyl transferase on bone marrow smears by immunoperoxidase.
- Ultrastructural comparison of Hodgkin''s and non-Hodgkin''s lymphomas.
- Histiocytic sarcoma with a granuloma-like component occurring in a large colony of Sprague-Dawley rats.
- Ultrastructural organization of the Reed-Sternberg cell: its resemblance to cells of the monocyte-macrophage system.
- Murine monoclonal antibodies (MCS-1 and MCS-2) reactive with human myeloid leukemia cells.
- Distributions of melanoma growth stimulatory activity of growth-regulated gene and the interleukin-8 receptor B in human wound repair.
- Identification and characterization of a promiscuous chemokine-binding protein in a human erythroleukemic cell line.
- Development and characterization of three recombinant single chain antibody fragments (scFvs) directed against the CD19 antigen.
- The promiscuous chemokine binding profile of the Duffy antigen/receptor for chemokines is primarily localized to sequences in the amino-terminal domain.
- De novo 1;10 balanced translocation in an infant with thanatophoric dysplasia: a clue to the locus of the candidate gene.
- The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.
- Posttransplantation plasma cell dyscrasias.
- Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, w...
- Cytometric detection of DNA amplified with fluorescent primers: applications to analysis of clonal bcl-2 and IgH gene rearrangements in malignant lymphomas.
- An investigation of the viral pathogenesis of Kikuchi-Fujimoto disease. Lack of evidence for Epstein-Barr virus or human herpesvirus type 6 as the causative agents.
- Consensus review of the clinical utility of DNA flow cytometry in neoplastic hematopathology.
- Angiocentric lymphoproliferative disorders of the respiratory system: incrimination of Epstein-Barr virus in pathogenesis.
- The Duffy antigen receptor for chemokines: structural analysis and expression in the brain.
- Identification of a major co-receptor for primary isolates of HIV-1.
- A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
- Lymphoblastoid transmembrane potential in bipolar patients, their siblings, and unrelated healthy comparison subjects.
- Leukocyte transmembrane potential in bipolar illness.
- Identification of the Fy6 epitope recognized by two monoclonal antibodies in the N-terminal extracellular portion of the Duffy antigen receptor for chemokines.
- Chemokines: molecular double agents.
- CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons.
- Expression of chemokine receptors by subsets of neurons in the central nervous system.
- Role of CCR5 in infection of primary macrophages and lymphocytes by macrophage-tropic strains of human immunodeficiency virus: resistance to patient-derived and protot...
- Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains.
- From malaria to chemokine receptor: the emerging physiologic role of the Duffy blood group antigen.
- Evolution of HIV-1 coreceptor usage through interactions with distinct CCR5 and CXCR4 domains.
- Two distinct CCR5 domains can mediate coreceptor usage by human immunodeficiency virus type 1.
- Unwelcomed guests with master keys: how HIV uses chemokine receptors for cellular entry.
- Promiscuous use of CC and CXC chemokine receptors in cell-to-cell fusion mediated by a human immunodeficiency virus type 2 envelope protein.
- Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalization.
- Expression of chemokine receptors in insect cells using baculovirus vectors.
- Chimeric chemokine receptors for analysis of structure-function relationships.
- Expression of chemokine receptors by endothelial cells: detection by intravital microscopy using chemokine-coated fluorescent microspheres.
- Detection of HIV proviral DNA on toothbrushes: a preliminary study.
- CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins.
- The solution structure of the anti-HIV chemokine vMIP-II.
- Expression of the chemokine receptor CXCR2 in normal and neoplastic neuroendocrine cells.
- Exaggerated response to endotoxin in mice lacking the Duffy antigen/receptor for chemokines (DARC).
- Identification of ENV determinants in V3 that influence the molecular anatomy of CCR5 utilization.
- Comparison of the structure of vMIP-II with eotaxin-1, RANTES, and MCP-3 suggests a unique mechanism for CCR3 activation.
- Evolution of the human immunodeficiency virus type 1 envelope during infection reveals molecular corollaries of specificity for coreceptor utilization and AIDS pathoge...
- Pharmacophore identification of a specific CXCR4 inhibitor, T140, leads to development of effective anti-HIV agents with very high selectivity indexes.
- Conformational study of a highly specific CXCR4 inhibitor, T140, disclosing the close proximity of its intrinsic pharmacophores associated with strong anti-HIV activity.
Schools
Saint Louis University School of Medicine
North Carolina Memorial Hospital
Doctors Specialties
- Pathology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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University of North Carolina Hospitals -
Saint Louis University School of Medicine
Hospital
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Thomas Jefferson University Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1184724080 |
| Last Name Of The Provider | PEIPER |
| First Name Of The Provider | STEPHEN |
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