Professor, Medicine, Perelman School of Medicine
Pulmonology
Dr. Michael F. Beers, MD
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Michael Beers works in the field of Pulmonology. He went to Perelman School of Medicine at the University of Pennsylvania. Doctor Michael F. Beers, MD is a published MD. He has 95 publications published. The most current publication "TGF-beta1 inhibits surfactant component expression and epithelial cell maturation in cultured human fetal lung."
Publications
- The role of inducible nitric oxide synthase for interstitial remodeling of alveolar septa in surfactant protein D-deficient mice.
- A non-BRICHOS SFTPC mutant (SP-CI73T) linked to interstitial lung disease promotes a late block in macroautophagy disrupting cellular proteostasis and mitophagy.
- Surfactant Dysfunction and Lung Inflammation in the Female Mouse Model of Lymphangioleiomyomatosis (LAM).
- NOS2 Is Critical to the Development of Emphysema in Sftpd Deficient Mice but Does Not Affect Surfactant Homeostasis.
- Disruption of N-linked glycosylation promotes proteasomal degradation of the human ATP-binding cassette transporter ABCA3.
- SP-D Regulates Effector Cell Function and Fibrotic Lung Remodeling in Response to Bleomycin Injury.
- Multiple ways to die: Delineation of the unfolded protein response and apoptosis induced by Surfactant Protein C BRICHOS mutants.
- A nonaggregating surfactant protein C mutant is misdirected to early endosomes and disrupts phospholipid recycling.
- Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs.
- The three R's of lung health and disease: repair, remodeling, and regeneration.
- Early alveolar epithelial dysfunction promotes lung inflammation in a mouse model of Hermansky-Pudlak syndrome.
- A novel conserved targeting motif found in ABCA transporters mediates trafficking to early post Golgi compartments.
- Segmental allergen challenge alters multimeric structure and function of surfactant protein d in humans.
- Endoplasmic reticulum stress induced by surfactant protein C BRICHOS mutants promotes proinflammatory signaling by epithelial cells.
- ANGPT2 Genetic Variant is Associated with Trauma-Associated Acute Lung Injury and Altered Plasma Angiopoietin-2 Isoform Ratio.
- Role of ER Stress in EMT of Alveolar Epithelial Cells: Effects of Misfolded Surfactant Protein.
- Review: Chemical and structural modifications of pulmonary collectins and their functional consequences.
- Anterograde transport of surfactant protein C proprotein to distal processing compartments requires PPDY-mediated association with Nedd4 ubiquitin ligases.
- Immune reconstitution during Pneumocystis lung infection: disruption of surfactant component expression and function by S-nitrosylation.
- Hyperoxia and acute lung injury.
- S-nitrosylation of surfactant protein-D controls inflammatory function.
- Surfactant protein D protects against acute hyperoxic lung injury.
- Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice.
- Misfolded BRICHOS SP-C mutant proteins induce apoptosis via caspase-4- and cytochrome c-related mechanisms.
- SP-D-deficient mice are resistant to hyperoxia.
- Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression.
- IL-4 and IL-13 form a negative feedback circuit with surfactant protein-D in the allergic airway response.
- Alveolar surfactant protein D content modulates bleomycin-induced lung injury.
- Coexpression of RTI40 with alveolar epithelial type II cell proteins in lungs following injury: identification of alveolar intermediate cell types.
- A surfactant protein C precursor protein BRICHOS domain mutation causes endoplasmic reticulum stress, proteasome dysfunction, and caspase 3 activation.
- Nonspecific interstitial pneumonia, alveolar proteinosis, and abnormal proprotein trafficking resulting from a spontaneous mutation in the surfactant protein C gene.
- Surfactant protein C biosynthesis and its emerging role in conformational lung disease.
- Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrog...
- Progressive lung disease and surfactant dysfunction with a deletion in surfactant protein C gene.
- Delayed clearance of pneumocystis carinii infection, increased inflammation, and altered nitric oxide metabolism in lungs of surfactant protein-D knockout mice.
- IL-4 induces production of the lung collectin surfactant protein-D.
- Surfactant protein-D, a mediator of innate lung immunity, alters the products of nitric oxide metabolism.
- Processing of surfactant protein C requires a type II transmembrane topology directed by juxtamembrane positively charged residues.
- The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice.
- Total extracellular surfactant is increased but abnormal in a rat model of gram-negative bacterial pneumonia.
- Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes.
- Biosynthesis of surfactant protein C (SP-C). Sorting of SP-C proprotein involves homomeric association via a signal anchor domain.
- Onshore catering increases the risk of diarrhoeal illness amongst cruise ship passengers.
- Operation Safe Haven: an evaluation of health surveillance and monitoring in an acute setting.
- Preparing for refugee crises in Australia: Kosovar health surveillance.
- H+ ATPase of chromaffin granules. Kinetics, regulation, and stoichiometry.
- Evidence for an ascorbate shuttle for the transfer of reducing equivalents across chromaffin granule membranes.
- A role for ipratropium in chemical terrorism preparedness.
- Very low surfactant protein C contents in newborn Belgian White and Blue calves with respiratory distress syndrome.
- Recurrent pneumothorax in AIDS patients with Pneumocystis pneumonia. A clinicopathologic report of three cases and review of the literature.
- Synthesis and processing of hydrophobic surfactant protein C by isolated rat type II cells.
- Structural requirements for intracellular targeting of SP-C proprotein.
- Aspergillus fumigatus-induced allergic airway inflammation alters surfactant homeostasis and lung function in BALB/c mice.
- SP-D-dependent regulation of NO metabolism in lipopolysaccharide-stimulated peritoneal macrophages.
- Nitric oxide production and perivascular nitration in brain after carbon monoxide poisoning in the rat.
- Differential extraction for the rapid purification of bovine surfactant protein B.
- Pneumocystis carinii glycoprotein A inhibits surfactant phospholipid secretion by rat alveolar type II cells.
- Inhibition of Trimeresurus flavoviridis phospholipase A2 by lung surfactant protein A (SP-A).
- ATP and adenosine 3',5'-cyclic monophosphate stimulate the synthesis of surfactant protein A in rat lung.
- Binding and uptake of surfactant protein B by alveolar type II cells.
- Surfactant protein B processing in human fetal lung.
- Inhibition of cellular processing of surfactant protein C by drugs affecting intracellular pH gradients.
- Surfactant protein C: a review of its unique properties and metabolism.
- Interstitial lung disease in a baby with a de novo mutation in the SFTPC gene.
- Surfactant proteins in pulmonary alveolar proteinosis in adults.
- Partial deficiency of surfactant protein B in an infant with chronic lung disease.
- Synthesis and post-translational processing of surfactant protein C.
- Inhibition of lung surfactant protein B expression during Pneumocystis carinii pneumonia in mice.
- TGF-beta1 inhibits surfactant component expression and epithelial cell maturation in cultured human fetal lung.
- Pneumocystis carinii pneumonia alters expression and distribution of lung collectins SP-A and SP-D.
- Maintenance of differentiated function of the surfactant system in human fetal lung type II epithelial cells cultured on plastic.
- Post-translational processing of surfactant protein-C proprotein: targeting motifs in the NH(2)-terminal flanking domain are cleaved in late compartments.
- Biosynthesis of surfactant protein C: characterization of aggresome formation by EGFP chimeras containing propeptide mutants lacking conserved cysteine residues.
- Expression and glucocorticoid regulation of surfactant protein C in human fetal lung.
- Surfactant protein B in human fetal lung: developmental and glucocorticoid regulation.
- Pulmonary surfactant metabolism in infants lacking surfactant protein B.
- Synthesis of type II cell lamellar body lysozyme-15 kD protein (lbl-15) by perfused rat lung.
- Respiratory distress after intratracheal bleomycin: selective deficiency of surfactant proteins B and C.
- P. carinii induces selective alterations in component expression and biophysical activity of lung surfactant.
- Synthetic processing of surfactant protein C by alevolar epithelial cells. The COOH terminus of proSP-C is required for post-translational targeting and proteolysis.
- Localization, synthesis, and processing of surfactant protein SP-C in rat lung analyzed by epitope-specific antipeptide antibodies.
- An antibody with specificity for surfactant protein C precursors: identification of pro-SP-C in rat lung.
- Susceptibility to ozone-induced airway inflammation is associated with decreased levels of surfactant protein D.
- Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis.
- Attenuated allergic airway hyperresponsiveness in C57BL/6 mice is associated with enhanced surfactant protein (SP)-D production following allergic sensitization.
- Surfactant protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses.
- Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease.
- Deletion of exon 4 from human surfactant protein C results in aggresome formation and generation of a dominant negative.
- Surfactant protein C: its unique properties and emerging immunomodulatory role in the lung.
- GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo.
- Chronic obstructive pulmonary disease and inhaled steroids alter surfactant protein D (SP-D) levels: a cross-sectional study.
- Comprehensive characterisation of pulmonary and serum surfactant protein D in COPD.
- Effect of single vs bilateral lung transplantation on plasma surfactant protein D levels in idiopathic pulmonary fibrosis.
- A non-BRICHOS surfactant protein c mutation disrupts epithelial cell function and intercellular signaling.
Schools
University Of Pennsylvania School Of Medicine
University Of Pa Health System
Doctors Specialties
- Critical Care Medicine
- Pulmonology
Accepted Insurances
Education
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University of Pennsylvania Health System -
Perelman School of Medicine at the University of Pennsylvania
Hospital
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Hospital of the University of Pennsylvania -
Philadelphia Veterans Affairs Medical Center
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