Physician
General Surgery
Dr. Harry H. Simms, MD
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Harry H. Simms, MD works in the field of General Surgery. He went to medical school at George Washington University School of Medicine. George Washington University School of Medicine is ranked 67 in research and 0 in primary care medicine Harry H. Simms, MD is a published doctor and has 96 publications published. The lastest was: 'Interleukin-8-induced suppression of polymorphonuclear leukocyte apoptosis is mediated by suppressing CD95 (Fas/Apo-1) Fas-1 interactions.' He is registered with Medicare.
Publications
- Multicenter clinical trial of recombinant human insulin-like growth factor I in patients with acute renal failure.
- Sexual behaviour, condom use and rates of sexually transmitted infections in HIV clinic attendees in South East London.
- Effect of chronic cocaine on cardioVascular responses to norepinephrine and acetylcholine in the conscious rat.
- Matrix protein regulation of PMN oxidative metabolism during ischemia.
- Altered oxygen tension modulates cytokine-induced signal transduction in polymorphonuclear leukocytes: regulation of the G PLC pathway.
- Polymorphonuclear leucocyte (PMN)-derived inflammatory cytokines--regulation by oxygen tension and extracellular matrix.
- Polymorphonuclear leukocyte opsonic receptor expression after hypoxia/reoxygenation.
- Regulation of polymorphonuclear neutrophil CD16 and CD11b/CD18 expression by matrix proteins during hypoxia is VLA-5, VLA-6 dependent.
- Regulation of polymorphonuclear leukocyte cytokine receptor expression: the role of altered oxygen tensions and matrix proteins.
- Hypoxemia/reoxygenation down-regulates interleukin-8-stimulated bactericidal activity of polymorphonuclear neutrophil by differential regulation of CD16 and CD35 mRNA ...
- Abdominal compartment syndrome: clinical manifestations and predictive factors.
- Adrenomedullin and adrenomedullin binding protein-1: their role in the septic response.
- Abdominal compartment syndrome in the surgical intensive care unit.
- Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.
- Tumor necrosis factor-alpha-stimulated polymorphonuclear leukocytes suppress migration and bactericidal activity of polymorphonuclear leukocytes in a paracrine manner.
- Role of primary breast cancer characteristics in predicting positive sentinel lymph node biopsy results: a multivariate Analysis.
- Predictive factors associated with the development of abdominal compartment syndrome in the surgical intensive care unit.
- Paracrine suppression of apoptosis by cytokine-stimulated neutrophils involves divergent regulation of NF-kappaB, Bcl-X(L), and Bak.
- Vasoactive hormone adrenomedullin and its binding protein: anti-inflammatory effects by up-regulating peroxisome proliferator-activated receptor-gamma.
- Ghrelin down-regulates proinflammatory cytokines in sepsis through activation of the vagus nerve.
- Adrenomedullin and adrenomedullin-binding protein-1 downregulate inflammatory cytokines and attenuate tissue injury after gut ischemia-reperfusion.
- Adrenomedullin and adrenomedullin binding protein-1 prevent metabolic acidosis after uncontrolled hemorrhage in rats.
- Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines.
- The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma.
- Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway.
- Mechanisms responsible for Vascular hyporesponsiveness to adrenomedullin after hemorrhage: the central role of adrenomedullin binding protein-1.
- Divergent roles of murine neutrophil chemokines in hemorrhage induced priming for acute lung injury.
- Gut-derived norepinephrine plays an important role in up-regulating IL-1beta and IL-10.
- Adrenomedullin and its binding protein attenuate the proinflammatory response after hemorrhage.
- A novel approach to maintaining cardioVascular stability after hemorrhagic shock: beneficial effects of adrenomedullin and its binding protein.
- NF-kappaB protects lung epithelium against hyperoxia-induced nonapoptotic cell death-oncosis.
- Regulation of polymorphonuclear leukocyte apoptosis: role of lung endothelium-epithelium bilayer transmigration.
- Delayed administration of human inter-alpha inhibitor proteins reduces mortality in sepsis.
- Adrenomedullin and adrenomedullin binding protein-1 attenuate Vascular endothelial cell apoptosis in sepsis.
- Differential expression of cytochrome P450 isoforms in the lungs of septic animals.
- Upregulation of cardioVascular ghrelin receptor occurs in the hyperdynamic phase of sepsis.
- Standardizing Vascular surgery residency: merger of two programs to create one model.
- Down-regulation of hepatic CYP1A2 plays an important role in inflammatory responses in sepsis.
- Transmigration across a lung epithelial monolayer delays apoptosis of polymorphonuclear leukocytes.
- Ghrelin clearance is reduced at the late stage of polymicrobial sepsis.
- Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity.
- Regulation of IL-8RA (CXCR1) expression in polymorphonuclear leukocytes by hypoxia/reoxygenation.
- Analysis of the effect of conversion from open to closed surgical intensive care unit.
- Interleukin-8-induced suppression of polymorphonuclear leukocyte apoptosis is mediated by suppressing CD95 (Fas/Apo-1) Fas-1 interactions.
- The role of neutrophil-derived oxidants as second messengers in interleukin 1beta-stimulated cells.
- Studies on polymorphonuclear leukocyte bactericidal function III: the role of extracellular matrix proteins.
- Integrin regulation of polymorphonuclear leukocyte apoxis during hypoxia is primarily dependent on very late activation antigens 3 and 5.
- Endogenous PMN-derived reactive oxygen intermediates provide feedback regulation on respiratory burst signal transduction.
- Integrin stimulation regulates polymorphonuclear leukocytes inflammatory cytokine expression.
- Abdominal compartment syndrome: case reports and implications for management in critically ill patients.
- Studies on polymorphonuclear leukocyte bactericidal function: II. The role of oxidative stress.
- Cytokine control of PMN phagocytosis: regulatory effects of hypoxemia and hypoxemia-reoxygenation.
- Posttraumatic auto-oxidative polymorphonuclear neutrophil receptor injury predicts the development of nosocomial infection.
- Studies on polymorphonuclear leukocyte bactericidal function: the role of exogenous cytokines.
- Alpha-defensin 1 (human neutrophil protein 1) as an antichemotactic agent for human polymorphonuclear leukocytes.
- Diagnosis of acute Cholecystitis: sensitivity of sonography, cholescintigraphy, and combined sonography-cholescintigraphy.
- Prolonged lactate clearance is associated with increased mortality in the surgical intensive care unit.
- Inhibition of Fas signaling prevents hepatic injury and improves organ blood flow during sepsis.
- A 9-year, single-institution, retrospective review of death rate and prognostic factors in adult respiratory distress syndrome.
- TNFalpha-induced suppression of PMN apoptosis is mediated through interleukin-8 production.
- Suppression of PMN apoptosis by hypoxia is dependent on Mcl-1 and MAPK activity.
- The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis.
- Neutrophils regulate their own apoptosis via preservation of CXC receptors.
- CXC chemokine suppression of polymorphonuclear leukocytes apoptosis and preservation of function is oxidative stress independent.
- Effects of fluconazole administration in critically ill patients: Analysis of bacterial and fungal resistance.
- IL-1beta stimulation induces paracrine regulation of PMN function and apoptosis.
- Role of granulocyte-macrophage colony-stimulating factor and its receptor in the genesis of acute respiratory distress syndrome through an effect on neutrophil apoptosis.
- Prognostic usefulness of scoring systems in critically ill patients with severe acute pancreatitis.
- Altered oxygen tension modulates cytokine-induced signal transduction in polymorphonuclear leukocytes: regulation of the GPLD pathway.
- Results of a randomized trial comparing sequential intravenous/oral treatment with ciprofloxacin plus metronidazole to imipenem/cilastatin for intra-abdominal infectio...
- Cytokine-mediated human polymorphonuclear neutrophil phagocytosis: evidence of differential sensitivities to manipulation of intracellular mechanisms.
- Polymorphonuclear leukocytes: their role as central cellular elements in shock pathogenesis.
- Hypoxia induces an opsonic mismatch on the polymorphonuclear leukocyte surface-reversal via Arg-Gly-Asp-Ser-mediated adhesion.
- Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome.
- Regulation of intracellular polymorphonuclear leukocyte Fc receptors by lipopolysaccharide.
- Hypoxemia regulates effect of lipopolysaccharide on polymorphonuclear leukocyte CD11b/CD18 expression.
- Gastric alkalinization does not increase the risk of pneumonia in critically ill patients.
- Lipopolysaccharide induces intracytoplasmic migration of the polymorphonuclear leukocyte CD11b/CD18 receptor.
- Regulation of whole blood polymorphonuclear leukocyte phagocytosis following hypoxemia and hypoxemia/reoxygenation.
- Hypoxemia up-regulates interleukin-8 stimulated phagocytosis of polymorphonuclear leukocytes by differential regulation of CD32w and CD35 messenger RNA expression.
- Subcellular location of neutrophil opsonic receptors is altered by exogenous reactive oxygen species.
- Granulocyte colony-stimulating factor reverses septic shock-induced polymorphonuclear leukocyte dysfunction.
- Studies on phagocytosis in patients with acute bacterial infections.
- Intraabdominal sepsis: effects on polymorphonuclear leukocyte Fc receptor-mediated phagocytosis.
- Untreated intra-abdominal sepsis: lack of synergism between polymorphonuclear leukocyte (PMN) complement receptors CR1/CR3 and IgG receptor FcRIII.
- Role of gastric colonization in the development of pneumonia in critically ill trauma patients: results of a prospective randomized trial.
- The effects of IL-1, IL-2, and tumor necrosis factor on polymorphonuclear leukocyte Fc gamma receptor-mediated phagocytosis. IL-2 down-regulates the effect of tumor ne...
- Monokines released during short-term Fc gamma receptor phagocytosis up-regulate polymorphonuclear leukocytes and monocyte-phagocytic function.
- Altered polymorphonuclear leukocyte Fc gamma R expression contributes to decreased candicidal activity during intraabdominal sepsis.
- Increased PMN CD11b/CD18 expression following post-traumatic ARDS.
- Intraabdominal sepsis: enhanced autooxidative effect on polymorphonuclear leukocyte cell surface receptor expression.
- Endotoxin suppresses matrix protein-induced upregulation of PMN candicidal activity: an effect reversed by low-dose TNF-alpha.
- Hypocalcemia during sepsis. Relationship to resuscitation and hemodynamics.
- Polymicrobial sepsis disrupts normal neutrophil extracellular matrix protein interactions.
- Intra-abdominal sepsis alters tumor necrosis factor-alpha and interleukin-1 beta binding to human neutrophils.
Schools
George Washington University School of Medicine And Health Sciences
Beth Israel Hospital
Miemss
Procedures Preformed
- Appendectomy, Open
- Colectomy
- Dressing and-or Debridement of Wound, Infection, or Burn (incl. Negative Pressure Wound Therapy)
- Excision of Parotid, Sublingual, or Submandibular Gland
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Conditions Treated
- Anal and Rectal Cancer
- Anorectal Abscess
- Appendicitis
- Atelectasis
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Doctors Specialties
- General Surgery
Accepted Insurances
Education
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Beth Israel Deaconess Medical Center -
George Washington University School of Medicine
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