Physician
Internal Medicine
Dr. George S. Worthen, MD
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George S. Worthen is an expert in the field of Internal Medicine. He graduated from Harvard Medical School. Harvard Medical School is a one of the best medicals schools. Harvard Medical School has a rank of 1 in research and a 12 in primary care Dr. George S. Worthen is also published. He has 101 publications published. The lastest publication: "Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection.'
Publications
- RBCs Induce Necroptosis of Lung Endothelial Cells and Increase Susceptibility to Lung Inflammation.
- CXCL5 is required for angiogenesis, but not structural adaptation after small bowel resection.
- Neutralizing Th2 Inflammation in Neonatal Islets Prevents β-Cell Failure in Adult IUGR Rats.
- The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice.
- Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation.
- Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice.
- Transcriptomic analysis comparing tumor-associated neutrophils with granulocytic myeloid-derived suppressor cells and normal neutrophils.
- Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-mediated signaling contributes to innate immune responses in the lung during Escherichia coli pne...
- Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
- Myeloid differentiation protein-2-dependent and -independent neutrophil accumulation during Escherichia coli pneumonia.
- A novel method for long term bone marrow culture and genetic modification of murine neutrophils via retroviral transduction.
- Polarization of tumor-associated neutrophil phenotype by TGF-beta: "N1" versus "N2" TAN.
- CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection.
- Infusion of mature megakaryocytes into mice yields functional platelets.
- IL-17A and TNF-? exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro.
- Neutrophil adherence induced by lipopolysaccharide in vitro. Role of plasma component interaction with lipopolysaccharide.
- Mechanisms of lipopolysaccharide-induced neutrophil retention. Relative contributions of adhesive and cellular mechanical properties.
- Effects of neutrophil depletion and repletion on PAF-induced hyperresponsiveness of canine trachea.
- Studies on the role of tumor necrosis factor in adult respiratory distress syndrome.
- Platelet-activating factor causes neutrophil accumulation and neutrophil-mediated increased vascular permeability in canine trachea.
- Biophysical properties and microfilament assembly in neutrophils: modulation by cyclic AMP.
- Neutrophil kinetics in the pulmonary microcirculation during acute inflammation.
- Biosynthesis of platelet activating factor and 1-O-acyl analogues by endothelial cells.
- Mechanical properties of HL60 cells: role of stimulation and differentiation in retention in capillary-sized pores.
- Fetal pulmonary vasodilation after exogenous platelet-activating factor.
- Control of local blood flow in pulmonary inflammation: role for neutrophils, PAF, and thromboxane.
- Activation of mechanical responses in leukocytes.
- Interaction between chemoattractants and bacterial lipopolysaccharide in the induction and enhancement of neutrophil adhesion.
- Retention of leukocytes in capillaries: role of cell size and deformability.
- Neutrophil kinetics in the pulmonary microcirculation. Effects of pressure and flow in the dependent lung.
- Leukocyte and platelet margination within microvasculature of rabbit lungs.
- Opposing hemodynamic effects of substance P on pulmonary vasculature in rabbits.
- Bacterial lipopolysaccharide enhances chemoattractant-induced elastase secretion by human neutrophils.
- Lipopolysaccharide stimulates monocyte adherence by effects on both the monocyte and the endothelial cell.
- Endotoxin-pretreated neutrophils increase pulmonary vascular permeability in dogs.
- Effect of PAF on parasympathetic contraction of canine airways.
- Mechanics of stimulated neutrophils: cell stiffening induces retention in capillaries.
- The association of circulating endotoxin with the development of the adult respiratory distress syndrome.
- The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion.
- Pentoxifylline decreases endotoxin-induced pulmonary neutrophil sequestration and extravascular protein accumulation in the dog.
- Physiological neutrophil sequestration in the lung: visual evidence for localization in capillaries.
- Enhancement of pulmonary inflammation by PGE2: evidence for a vasodilator effect.
- Neutrophil retention in model capillaries: deformability, geometry, and hydrodynamic forces.
- Neutrophil-mediated pulmonary vascular injury. Synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil...
- Monocyte retention and migration in pulmonary inflammation. Requirement for neutrophils.
- Neutrophil-mediated injury to endothelial cells. Enhancement by endotoxin and essential role of neutrophil elastase.
- Lung vascular injury induced by chemotactic factors: enhancement by bacterial endotoxins.
- The pulmonary vascular sequestration of neutrophils in endotoxemia is initiated by an effect of endotoxin on the neutrophil in the rabbit.
- Lipid mediators, neutrophils, and endothelial injury.
- Effects of shear stress on adhesive interaction between neutrophils and cultured endothelial cells.
- Additive effect of intravascular complement activation and brief episodes of hypoxia in producing increased permeability in the rabbit lung.
- Mechanisms of acute lung injury.
- Altering hydrodynamic variables influences PGI2 production by isolated lungs and endothelial cells.
- Platelet-activating factor causes neutrophil accumulation and edema in rabbit lungs.
- IL-8 signal transduction in human neutrophils.
- Disparate role of the beta 2-integrin CD18 in the local accumulation of neutrophils in pulmonary and cutaneous inflammation in the rabbit.
- Neutrophil response to endotoxin in the adult respiratory distress syndrome: role of CD14.
- Paradoxic effect of ibuprofen on neutrophil accumulation in pulmonary and cutaneous inflammation.
- Migration-associated volume changes in neutrophils facilitate the migratory process in vitro.
- Lipopolysaccharide-induced monocyte retention in the lungs of rabbits. Role of cell stiffness and the CD11/CD18 leukocyte adhesion complex.
- Lipolysaccharide-induced monocyte retention in the lung. Role of monocyte stiffness, actin assembly, and CD18-dependent adherence.
- FMLP activates Ras and Raf in human neutrophils. Potential role in activation of MAP kinase.
- Mapping of the C5a receptor signal transduction network in human neutrophils.
- Role of tyrosine kinases and MAP kinase in neutrophils stimulated by lipopolysaccharide.
- Neutrophils increase volume during migration in vivo and in vitro.
- Selective coupling of the human anaphylatoxin C5a receptor and alpha 16 in human kidney 293 cells.
- Neutrophil sequestration and migration in localized pulmonary inflammation. Capillary localization and migration across the interalveolar septum.
- Interleukin-8 regulation of the Ras/Raf/mitogen-activated protein kinase pathway in human neutrophils.
- Activation of a p38 mitogen-activated protein kinase in human neutrophils by lipopolysaccharide.
- Activation of MEKK by formyl-methionyl-leucyl-phenylalanine in human neutrophils. Mapping pathways for mitogen-activated protein kinase activation.
- Common and distinct intracellular signaling pathways in human neutrophils utilized by platelet activating factor and FMLP.
- Interleukin 8-stimulated phosphatidylinositol-3-kinase activity regulates the migration of human neutrophils independent of extracellular signal-regulated kinase and p...
- Age-dependent neutrophil and blood flow responsiveness in acute pulmonary inflammation in rabbits.
- Neutrophil-platelet adhesion: relative roles of platelet P-selectin and neutrophil beta2 (DC18) integrins.
- p38 mitogen-activated protein kinase-dependent and -independent intracellular signal transduction pathways leading to apoptosis in human neutrophils.
- Intracellular signaling by the chemokine receptor US28 during human cytomegalovirus infection.
- Selective activation and functional significance of p38alpha mitogen-activated protein kinase in lipopolysaccharide-stimulated neutrophils.
- Clofazimine crystals in the cytoplasm of pulmonary macrophages.
- An intracellular signaling pathway linking lipopolysaccharide stimulation to cellular responses of the human neutrophil: the p38 MAP kinase cascade and its functional ...
- Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse.
- Role of p38 mitogen-activated protein kinase in a murine model of pulmonary inflammation.
- Tumor necrosis factor-alpha activation of the c-Jun N-terminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine...
- Viral regulation of RANTES expression during human cytomegalovirus infection of endothelial cells.
- Neutrophil maturation and activation determine anatomic site of clearance from circulation.
- Cross-talk between ERK and p38 MAPK mediates selective suppression of pro-inflammatory cytokines by transforming growth factor-beta.
- Overexpression of matrix metalloproteinase-7 in pulmonary fibrosis.
- Lipopolysaccharide stimulation of the human neutrophil: an analysis of changes in gene transcription and protein expression by oligonucleotide microarrays and proteomics.
- A genomic and proteomic analysis of activation of the human neutrophil by lipopolysaccharide and its mediation by p38 mitogen-activated protein kinase.
- Role of the E1A Rb-binding domain in repression of the NF-kappa B-dependent defense against tumor necrosis factor-alpha.
- A role for protein phosphatase-2A in p38 mitogen-activated protein kinase-mediated regulation of the c-Jun NH(2)-terminal kinase pathway in human neutrophils.
- Human cytomegalovirus protects endothelial cells from apoptosis induced by growth factor withdrawal.
- Selective suppression of neutrophil accumulation in ongoing pulmonary inflammation by systemic inhibition of p38 mitogen-activated protein kinase.
- Microarray analysis of lipopolysaccharide-treated human neutrophils.
- Lipopolysaccharide stimulates p38-dependent induction of antiviral genes in neutrophils independently of paracrine factors.
- Human pulmonary chimerism after hematopoietic stem cell transplantation.
- The in vitro production and characterization of neutrophils from embryonic stem cells.
- The in vitro differentiation of mouse embryonic stem cells into neutrophils.
- Lipopolysaccharide-induced c-Jun NH2-terminal kinase activation in human neutrophils: role of phosphatidylinositol 3-Kinase and Syk-mediated pathways.
- Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis.
- Pigment epithelium-derived factor in idiopathic pulmonary fibrosis: a role in aberrant angiogenesis.
Schools
Harvard Medical School
Doctors Specialties
- Critical Care Medicine
- Pulmonology
- Internal Medicine
Accepted Insurances
Education
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University of Colorado -
Beth Israel Deaconess Medical Center -
Harvard Medical School
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